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    "text": "Multiple Sclerosis Journal 29(6)\n\nTable 1. Characteristics of the study population.\n\nMale\n\nFemale\n\nOverall\n\nMS subjects\n\nControl subjects\n\np-value MS subjects Control subjects\n\np-value\n\nMS subjects\n\nControl subjects\n\np-value\n\nN Follow-up time (years) Female (%) Age (years) Ethnicity – white (%) Smoking status (%) Non-smoker Ex-smoker Current smoker eFI ratio Fit Mid frailty Moderate frailty Severe frailty Number of primary care visits in previous year Index of multiple deprivation (IMD; %)",
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    "text": "3685 9.9 (6.1)\n\n46.3 (13.3) 92.3\n\n41.5 17.5 41.1\n\n0.02 (0.04) 97.2 2.8 0.0 0.0 6.9 (10.3)\n\n21,931 11.4 (6.5)\n\n<0.001\n\n46.3 (13.3) 93.5\n\n0.852 0.013\n\n53.8 14.7 31.6 0.01 (0.03) <0.001 98.3 1.6 0.0 0.0 2.2 (5.0)\n\n<0.001\n\n<0.001\n\n<0.001\n\n8566 10.4 (6.3)\n\n44.3 (13.3) 91.5\n\n49.5 13.9 36.6\n\n0.03 (0.04) 95.8 4.0 0.2 0.0 8.2 (11.5)\n\n50,640 11.5 (6.5)\n\n<0.001\n\n44.3 (13.3) 94.1\n\n0.907 <0.001\n\n60.0 11.6 28.5 0.02 (0.04) <0.001 97.1 2.8 0.1 0.0 3.2 (6.1)\n\n<0.001\n\n<0.001\n\n<0.001\n\n12,251 10.3 (6.3)",
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    "text": "69.9 44.9 (13.3) 93.9\n\n47.1 15 37.9\n\n0.03 (0.04) 96.2 3.7 0.1 0.0 7.8 (11.2)\n\n72,572 11.5 (6.5)\n\n<0.001\n\n69.8 44.9 (13.3) 91.2\n\n0.752 0.727 <0.001\n\n58.1 12.5 29.4 0.02 (0.04) <0.001 97.4 2.5 0.1 0.0 2.9 (5.9)\n\n<0.001\n\n<0.001\n\n<0.001\n\n1Q – least deprived\n\n2Q 3Q 4Q\n\n5Q – most deprived Missing data\n\n13.7\n\n18.5 17.6 20.2 20.6\n\n9.3\n\n13.7\n\n18.4 17.6 20.3 20.6\n\n9.4\n\n1.000\n\n14.6\n\n18.5 17.9 18.8 20.3\n\n9.8\n\n14.6\n\n18.5 17.9 18.8 20.3\n\n9.9\n\n1.000\n\n14.4\n\n18.5 17.8 19.2 20.4\n\n9.7\n\n14.4\n\n18.5 17.8 19.2 20.4",
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    "text": "9.7\n\n1.000\n\nIndividuals were classified as fit, if the eFI score was below 0.12; mildly frail, if the score was between 0.12 and 0.24; moderately frail, if the score was between 0.24 and 0.36; severely frail, if the score was 0.36 and above. Differences between groups were assessed employing Chi-square test, Student’s t-test and the Kruskal–Wallis test, as appropriate.",
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    "text": "was even lower in men (PR = 0.27, 95% CI = 0.18, 0.39) than in women (PR = 0.38, 95% CI = 0.30, 0.49; Figure 1), but the difference was not statistically sig- nificant (p = 0.097).\n\nHyperlipidaemia. Treatment with lipid-lowering medications was lower in PwMS, as compared with matched controls (PR = 0.63, 95% CI = 0.54, 0.74). This was particularly pronounced for men (women: PR = 0.71, 95% CI = 0.59, 0.87; men: PR = 0.41, 95% CI = 0.37, 0.62).\n\nDifferences in risk factor severity",
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    "text": "As compared with matched controls, after adjustment, PwMS had a 0.4-mm Hg lower systolic blood",
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    "text": "pressure at the index year. The magnitude was greater for men than women, considering that men had almost a 3-mm Hg lower blood pressure than matched con- trols (overall: coeff. = −0.37, 95% CI = −0.60, −0.13; women: −0.54, 95% CI = −0.96, −0.12; men: −2.81, 95% CI = −3.84, −1.77). The differences were greater when restricting analyses to only those with a diagno- sis of hypertension at baseline, as PwMS had a 3.3- mm Hg lower systolic blood pressure then matched controls (coeff. = −3.27, 95% CI",
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